CORDIS Project
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The project focuses on understanding the structure and function of the transcription factor IIIB, which is essential for the initiation of RNA polymerase III transcription. By using advanced imaging techniques, it aims to reveal how this factor interacts with RNA polymerase and its role in gene regulation and cancer.
Gene transcription is a highly regulated process that allows cells to adapt during different stages of development and to changes in their environmental conditions.
Specifically, RNA polymerase (Pol) III is responsible for the transcription of small, untranslated genes involved in fundamental cellular process such as mRNA processing (U6 snRNA) and translation (tRNAs).
Recruitment of Pol III to its transcription start site requires the general transcription factor IIIB (TFIIIB), in mammals a know…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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