CORDIS Project
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This project focuses on improving CAR T cell therapy for solid tumors by investigating how biomechanical factors contribute to T cell exhaustion. It aims to develop microfluidic models and synthetic biological devices that can counteract T cell dysfunction, enhancing the effectiveness of cancer treatments.
Cancer is the second leading cause of death in the European Union, having killed 1.4 million people in 2018 alone.
Chimeric antigen receptor (CAR) T cell therapy is a ground-breaking cancer treatment that has demonstrated striking results in fighting blood cancers.
However, T cell exhaustion, a process that results in the progressive development of lymphocyte dysfunction due to prolonged antigen stimulation in cancer, chronic inflammation or infection, has been a major obstacle in translating CA…
FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA
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