CORDIS Project
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This project investigates the role of TET2 protein in colorectal cancer development. By examining the effects of TET2 deficiency on DNA methylation and tumor growth, it aims to identify potential biomarkers and therapeutic targets for improving treatment outcomes in colorectal cancer patients.
Colorectal cancer (CRC) results from the accumulation of genetic and epigenetic changes in colonic epithelial cells.
Epigenome studies revealed that virtually all CRCs contain aberrantly methylated genes and perturbed methylation patterns.
Ten-Eleven Translocation (TET) protein family dioxygenases oxidize 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) and further to other oxidized 5mCs, supporting active DNA demethylation and helping maintain epigenomic stability.
Loss of TET1 is an on…
UNIVERSITA DEGLI STUDI DI PAVIA
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