CORDIS Project
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This project investigates the role of the MYCN oncoprotein in neuroblastoma, focusing on its interactions with RNA and the nuclear exosome. The research aims to understand how MYCN regulates RNA degradation and DNA damage, potentially revealing new therapeutic targets for aggressive tumors.
The inherent stresses arising from oncogenic transcription can be counteracted by premature termination which removes RNA polymerase II (RNAPII) from DNA and enables the degradation of aberrant nascent RNA by the nuclear exosome.
When overexpressed, the MYCN oncoprotein fuels the growth of aggressive tumors by globally binding active promoters and invariably enhancing RNAPII transcription.
However, I have made two key discoveries showing that the function of MYCN is not restricted to gene activa…
JULIUS-MAXIMILIANS-UNIVERSITAT WURZBURG
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