CORDIS Project
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This project investigates a newly discovered cellular mechanism that helps cancer cells survive replication stress, particularly in triple-negative breast cancer. It aims to identify and target this mechanism for potential therapeutic interventions, improving treatment options for patients with difficult-to-treat tumor…
Genomic instability characterizes tumors, which have no clear ‘oncogenic-driver’ mutation, including triple-negative breast cancers (TNBCs).
These patients do not benefit from molecularly targeted treatment and urgently need better treatment options.
Increasing evidence points to replication stress as the driver of genomic instability.
Since replication stress compromises cell viability, cells have evolved mechanisms to mitigate this threat.
Recently, I discovered a novel cellular mechanism—mito…
UNIVERSITAIR MEDISCH CENTRUM GRONINGEN
ACADEMISCH ZIEKENHUIS GRONINGEN
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