CORDIS Project
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This project investigates how mechanical forces influence cell behavior by focusing on the interaction between CDK1 and talin, a key protein in cell adhesion. Using advanced single-molecule technology, the research aims to elucidate the mechanisms of talin phosphorylation and its role in focal adhesion dynamics during…
Mechanical forces are increasingly recognized as key regulators of cell behavior, acting alongside traditional chemical and electrical cues.
These forces are detected at focal adhesions (FAs), large multiprotein complexes thar convert physical stimuli into biochemical signals that control key cellular processes.
During mitotic entry, however, FAs must disassemble to ensure correct chromosome segregation, suggesting a tightly regulated interplay between adhesion dynamics and cell cycle progressio…
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