CORDIS Project
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This project aims to understand how the timing of neuronal development affects brain function and plasticity. By manipulating mitochondrial function in different species, it explores the impact of maturation rates on synaptic functions and potential therapeutic applications for brain diseases.
The timing of neuronal development is highly variable depending on the cell type or species.
In particular human cortical neurons display a considerably protracted tempo of development, at the basis of human brain neoteny.
The mechanisms underlying neuronal neoteny start to be unravelled, but their significance for brain function and plasticity remain poorly known, despite their implications for brain diseases and repair.
This project will combine innovative technologies developed by the applica…
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