CORDIS Project
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This project investigates the impact of telomere dysfunction on the immune system in aging. It aims to test the efficacy of specific oligonucleotides in rejuvenating immune responses, particularly vaccine effectiveness, in aged mice models.
The immune system is remodeled with age, going through a series of changes known as “immunosenescence’, including the involution of primary lymphoid organs, the contraction of the immune repertoire, a progressive lineage skewing towards the myeloid lineage and a low-grade pro-inflammatory status. A consequence of immunosenescence impacting the morbidity and mortality of infectious diseases is a dramatically reduced vaccine response in the elderly.
Thus, reducing the burden of immunosenescence ha…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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