CORDIS Project
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This project investigates the formation of spontaneous telomere fusions in the model organism Schizosaccharomyces pombe. It aims to uncover the proteins involved in telomere biology and their implications for genomic stability and cancer.
Telomeres are DNA-protein complexes that reside at the end of the chromosomes.
These are key structures in order to prevent loss of genetic information and DNA damage activation at the chromosome termini, thus avoiding genomic instability, which can potentiate tumorigenesis.
When a telomere became dysfunctional, for example by loss of telomeric proteins or due to telomere shortening, the DNA damage machinery is activated and the chromosome ends are processed as DNA breaks.
This leads to checkpoi…
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