CORDIS Project
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This project explores the role of non-coding RNA in the DNA damage response, particularly in aging. It aims to understand how these RNA molecules contribute to the activation of cellular mechanisms that maintain genome integrity, especially at the ends of chromosomes known as telomeres.
Genome instability is a hallmark of cellular and organismal aging.
Cells evolved a prompt set of actions known as the DNA damage response (DDR) to preserve genome integrity.
Until very recently, DDR pathways have been studied as networks of interacting proteins only.
We discovered that the full activation of the DDR pathways depends also on long and short damage-induced non coding RNA synthesised from exposed DNA ends of DNA double-strand breaks (DSB).
Inhibitory antisense oligonucleotides (ASO)…
IFOM-ISTITUTO FONDAZIONE DI ONCOLOGIA MOLECOLARE ETS
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