CORDIS Project
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This project explores how nutrient signaling affects the early stages of colorectal cancer development. By using Drosophila models, it aims to understand the interaction between intestinal stem cells and their environment in tumorigenesis.
Colorectal cancer (CRC) is the second most common cancer and nutrition influences its prevalence. CRC originates from intestinal stem cells (ISCs) and is initiated by specific genetic alterations, which influence cell growth, proliferation and fate.
How nutrient signalling within the mutated ISCs and the surrounding tissue environment influences the early steps of CRC tumorigenesis and whether genetically distinct tumour types react differently to nutrition remains poorly understood.
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