CORDIS Project
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This project explores the role of apolipoprotein A-I in regulating T cell functions related to atherosclerosis. By using genetically modified mice, it aims to understand how T cell activity influences inflammation and plaque development in cardiovascular disease.
The pathogenesis of atherosclerosis involves inflammation and immune reactions. T cell responses contribute to local inflammation and growth of the atherosclerotic plaque.
As intensified inflammatory activation may lead to local proteolysis, plaque rupture, and formation of a thrombus, studies of conventional and regulatory T cell functions during hypercholesterolemia are of outmost importance.Low levels of high-density lipoprotein (HDL) cholesterol are associated with inflammatory and immune di…
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