CORDIS Project
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This project focuses on the synthesis and structural analysis of a natural compound with potent antituberculosis properties. It includes the development of analogues to optimize efficacy and identify biological targets.
This project is directed toward the total synthesis and full structural elucidation of an epidithiodiketopiperazine natural product endowed with highly potent antituberculosis properties and whose full structure and biological evaluation remain incomplete due to its natural scarcity.
The proposed research program also includes design, synthesis and biological evaluation of novel analogues of the target molecule as part of an optimization effort, and attempts to identify its biological target.The…
UNIVERSITE DE GENEVE
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