CORDIS Project
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This project investigates the immune response in tuberculosis patients using whole genome analysis of blood samples. It aims to identify key genetic signatures and mechanisms involved in TB pathogenesis, utilizing mouse models to further explore the role of specific immune factors in disease progression.
I initiated and developed an unbiased comprehensive study using whole genome array analysis of the transcriptome in blood of tuberculosis (TB) patients and provided global knowledge of the immune response and potential factors leading to TB pathogenesis.
Using larger cohorts of TB patients and controls than previous studies, together with complementary analytical approaches of modular, pathway and gene level analysis, we identified a striking interferon (IFN)-inducible neutrophil-driven signatur…
THE FRANCIS CRICK INSTITUTE LIMITED
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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