CORDIS Project
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This project focuses on understanding how transcription factors regulate gene expression on the inactive X chromosome in female mammals. It employs advanced genomic techniques to uncover the mechanisms of gene regulation and their implications for X-linked disorders.
Transcription factor (TF) cooperativity controls gene expression and is essential to establish transcriptional programs during development.
One of the hallmarks of development in female mammals is the inactivation of one of the two X chromosomes to achieve dosage compensation of X-linked genes.
Although the inactive X (Xi) chromosome is a heterochromatin environment, a small fraction of genes is expressed from this chromosome.
However, the exact mechanisms regulating their expression and the pos…
EUROPEAN MOLECULAR BIOLOGY LABORATORY
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