CORDIS Project
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This project investigates the vulnerabilities in solid tumors with specific mutations in the SWI/SNF chromatin remodeling complex. By exploring how these defects affect DNA damage response and tumor immunity, the research aims to develop new therapeutic strategies to enhance treatment efficacy in resistant tumors.
Recent large-scale genomic profiling studies have uncovered mutations in the SWI/SNF (SWItch / Sucrose Non-Fermentable) chromatin remodelling complex subunits in 20% of solid tumours.
Most of these tumours resist to current therapies.
To address this highly unmet medical need, it is crucial to determine how to harness vulnerabilities induced by SWI/SNF defects.
Recent evidence shows that SWI/SNF influences the DNA damage response and is involved in shaping tumour immunogenicity.
Though, whether…
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