CORDIS Project
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This project aims to develop molecular inhibitors targeting the BMP4/pSMAD/CDX-2 pathway to reverse Barrett's esophagus, a condition linked to esophageal cancer. By creating a transgenic mouse model, the research seeks to evaluate the effectiveness of these inhibitors for potential clinical applications.
One of the consequences of the high Socio-economical standards is the increase of diseases related to abdominal obesity, such as gastro-esophageal reflux disease.
Barrett’s esophagus is a mucosal adaptation to chronic reflux disease, which is associated with an increased risk of developing esophageal adenocarcinoma.
This cancer has become a significant health burden.
One effective strategy to control further increase of this highly malignant cancer would be by population wide eradication of Barr…
ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM
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