CORDIS Project
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This project investigates how disabling DNA repair pathways in cancer cells can enhance anti-tumor immune responses. By exploring the relationship between DNA repair deficiencies and immune activation, the project aims to develop new cancer therapies that exploit these mechanisms for better patient outcomes.
This project will test for the first time the hypothesis that therapeutic inactivation of DNA repair pathways in cancer cells can be exploited for patient benefit by reawakening an anti-tumor immune response.Genomic instability and molecular heterogeneity, which occur in cancer cells with DNA repair deficiencies, fuel tumour progression and are associated with poor outcome.
An exception is represented by Mismatch repair (MMR) deficient cancers as these tumours are exceedingly genetically heterog…
UNIVERSITA DEGLI STUDI DI TORINO
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Italy, MILAN
Type: SME
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: Yes
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