CORDIS Project
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The TaPPiNG-EPI project investigates the role of the P2X7 receptor in epilepsy using human-derived neurons and glial cells. It aims to identify the cell types involved in P2X7 receptor activation and assess the potential of P2X7 receptor antagonists as therapeutic options.
Epilepsy is a neurological disorder characterized by recurrent seizures affecting 65 million people worldwide of which 6 million live in Europe alone with around 30% of patients not responding to currently available treatment.
The ATP-gated P2X7 receptor (P2X7R) has recently emerged as a promising target for epilepsy, showing anticonvulsant and disease-modifying properties in animal models.
However, to develop P2X7R-based therapeutics the cell types involved in pathological P2X7R activation must…
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