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The TANYFEEDNEURONS project investigates the role of tanycytes, specialized brain cells, in regulating food intake by interacting with neurons that control appetite. It aims to understand how these cells communicate and respond to metabolic changes, potentially leading to new treatments for metabolic disorders.
Tanycytes are specialized hypothalamic glial cells located at the interface between blood, cerebrospinal fluid (CSF) and brain areas that control food intake.
Little is known about their physiological roles.
Recent studies indicate that tanycytes sense the extracellular glucose, release the intercellular messenger adenosine triphosphate (ATP) and the energy metabolite lactate, both of which can potentially modulate neuronal activity.
Tanycytes also transport the blood-borne anorexigenic peptide…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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