CORDIS Project
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This project focuses on developing an efficient synthesis method for a group of cytotoxic natural products derived from Polythia Crassa. By utilizing novel tandem reaction sequences, the project aims to create structurally diverse analogues for testing against human tumor cell lines to improve their effectiveness and p…
A proposal for the concise synthesis of a family of cytotoxic natural products obtained from Polythia Crassa is contained herein.
The short and highly effcient synthesis accesses all the structurally diverse family members from two simple common precursors.
The synthesis makes use of novel tandem reaction sequences to access these molecules.
The molecules and their syntheses are amenable to the inclusion of structural modifications and libraries of structurally diverse analogues will therefore b…
PANEPISTIMIO KRITIS
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