CORDIS Project
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This project investigates the molecular mechanisms regulating bone formation, focusing on the roles of sclerostin and LRP5 in bone disorders. It aims to understand genetic variations affecting bone architecture and develop potential treatments for osteoporosis through targeted interventions.
The balance between bone resorption and bone formation determines the mass and structural integrity of the skeleton and is disturbed in osteoporosis.
In contrast to the molecular mechanisms regulating bone resorption, knowledge of the mechanisms regulating bone formation is limited. A recent breakthrough has been the identification of a link between bone mass in humans with rare bone disorders and gain- or loss-of function mutations of the Wnt co-receptor LRP5 or the Wnt antagonist sclerostin. T…
Leiden University Medical Center
ACADEMISCH ZIEKENHUIS LEIDEN
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Belgium, Antwerpen
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
THE CHANCELLOR MASTERS AND SCHOLARS OF THE UNIVERSITY OF CAMBRIDGE
United Kingdom, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Germany, Wuerzburg
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Switzerland, Geneve
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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