CORDIS Project
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This project investigates a novel population of immune cells, Th9 cells, and their role in inflammation and cancer. It aims to understand the molecular mechanisms that enhance their anticancer properties, potentially leading to new approaches in cancer immunotherapy.
Differentiation of naïve CD4 T cells in presence of TGF-beta and IL-4 has led to the identification of a novel IL-9-secreting-population of CD4 T cells, Th9 cells, which are characterized by their potent IL-9 release and their ability to induce proinflammatory responses in vivo.
Co-transfer of in vitro differentiated Th9 cells from naïve T cells along with effector cells increase the severity of colitis in mice.
Proinflammatory functions of Th9 cells have also been documented in the mouse model…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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