CORDIS Project
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This project aims to investigate the virulence factors of Pseudomonas aeruginosa, focusing on two phospholipases involved in bacterial infections. It seeks to understand their role in infection mechanisms and their impact on host cell signaling pathways.
IntroductionPseudomonas aeruginosa (Pa), a nosocomial pathogen, secretes a wide range of virulence factors. A recently described secretion pathway is the type VI secretion system (T6SS).
Pa encodes three T6SSs, H1-, H2- and H3-T6SS.
The best-characterized H1-T6SS is involved in delivering toxins into bacterial competitors.State-of-the artTwo phospholipases (Pld), PldA and PldB secreted via H2- and H3-T6SS, respectively, were recently identified as trans-kingdom virulence effectors, triggering bo…
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