CORDIS Project
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This project investigates the Type VI secretion system in Pseudomonas aeruginosa, a pathogen responsible for severe infections. It aims to identify secreted proteins from two lesser-studied secretion systems, enhancing understanding of bacterial virulence and potential therapeutic targets.
Pseudomonas aeruginosa is a human pathogen causing life-threatening nosocomial infections.
Its virulence mechanisms are pleiotropic, but secretion systems have a key role in transporting effectors, toxins and other virulence factors from the bacteria into the environment or target host cells.
In recent years, a novel secretion system, the Type VI secretion system (T6SS), was shown to be important for P. aeruginosa virulence.
Of three T6SSs encoded on the P. aeruginosa genome, the H1-T6SS is impo…
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