CORDIS Project
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This project investigates how the bacterium Neisseria meningitidis crosses blood-tissue barriers to invade the brain and vital organs. It explores the role of bacterial pili in disrupting cell junctions, utilizing advanced imaging and molecular techniques to enhance understanding of bacterial invasion and its implicati…
The main goal of this proposal is to determine how the deadly bacterial pathogen, Neisseria meningitidis (NM), crosses the blood-tissue barriers and invades the brain and other vital organs.
The main hypothesis behind this project is that NM, by interacting with the vascular endothelial cells with its pili, induces a signal that opens cell-to-cell junctions and allows the bacteria to penetrate the natural barriers using the paracellular route rather than the transcellular one as currently accept…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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