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The T-FRAME project investigates programmed ribosome frameshifting in human cells, particularly during HIV infection. By utilizing advanced techniques, it aims to understand how RNA structure and regulatory factors influence gene expression and could lead to new antiviral therapies.
The coding region of many genes contains sequence elements that constitute roadblocks during mRNA translation.
These roadblocks present problems, but also opportunities for the cell to increase the coding capacity of the genome by so-called programmed ribosome frameshifting (PRF). PRF is a universal gene expression strategy that brings plasticity to the proteome.
It is widely studied in viruses and bacteria, yet poorly understood in humans.My own mechanistic discoveries have highlighted that, re…
UNIVERSITAET REGENSBURG
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