CORDIS Project
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This project investigates follicular helper T cells and their interactions with B cells, focusing on their role in the germinal center reaction, which is crucial for developing effective immune responses and vaccines. The research aims to uncover the regulatory mechanisms of Tfh cells to improve therapeutic strategies…
Follicular helper T cells (Tfh), through their cognate interactions with B cells, drive the Germinal Center (GC) reaction resulting in affinity matured memory B cells and Plasma cells, hallmarks of the adaptive immunity and underpinning our ability to counter pathogenic insults.
For mounting a successful response against most pathogens, including the virus SarS-CoV-2 that has crippled most nations for over a year, Tfh cells are of central importance.
Aberrant activation of Tfh has also been impl…
UNIVERSITETET I OSLO
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