CORDIS Project
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This project investigates how the structure of DNA influences gene regulation, focusing on the HoxD locus in mice. By integrating genetics, biochemistry, and evolutionary analysis, it aims to model large-scale gene regulation during development and understand its evolutionary context.
The aim of this grant is to understand the relationships between genomic topology and the control of transcription, using the HoxD locus as a paradigm.
We will take a system approach in the mouse, combining tools of genetics, evolutionary genomics and biochemistry to try and model various modes of large-scale gene regulations occurring during development.
The results will tell us about the mechanistic bases of global gene regulation and how such regulations evolved, by integrating these mechanis…
ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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