CORDIS Project
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This project investigates how graded signals, specifically Sonic Hedgehog, influence the identity of progenitor cells in the developing spinal cord. By analyzing gene regulatory networks and transcription factors, it aims to understand the mechanisms of neural tube development and their implications for spinal cord the…
In many developing tissues, initially equipotent cells acquire their intended identity by exposure to extrinsic, graded signals termed morphogens, such as Sonic Hedgehog (Shh).
In the ventral neural tube, Shh induces 5 progenitor domains in a precise spatial order along the dorsoventral axis of the developing spinal cord.
These domains can be distinguished by the expression of different combinations of transcription factors (TFs).
During their specification, the progenitors transit through sever…
MEDICAL RESEARCH COUNCIL
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