CORDIS Project
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This project integrates mass spectrometry and DNA sequencing to explore how proteins interact with chromatin modifications during stem cell differentiation. By using intestinal organoid cultures, it aims to uncover the molecular mechanisms that regulate adult stem cell behavior, with implications for cancer research an…
Mass spectrometry-based proteomics and next generation DNA sequencing emerged as two powerful and complementary technologies in biology. I was the first to integrate these technologies in the area of epigenetics to identify and functionally characterize proteins that interact with post-translational modifications on histones and (hydroxy)methylated DNA (so-called chromatin ‘readers’).
My pioneering work revealed that an intricate networks of transcription factors, chromatin modifications and chr…
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