CORDIS Project
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This project explores the role of membrane trafficking in cellular functions and its implications for human diseases. By mapping membrane trafficking genes and proteins in specialized cells, it aims to understand their regulation and interaction, potentially revealing insights into tissue-specific disorders.
Membrane trafficking is fundamental for homeostasis of the internal membrane system and transport to and from the extracellular medium.
Although we have gained detailed knowledge on the molecular organization of membrane trafficking machineries a global view of its function and regulation is lacking.
To date membrane trafficking is often regarded as a constitutive process with a high degree of functional redundancy.
However, the fact that mutations of single trafficking genes with ubiquitous ex…
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