CORDIS Project
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This project explores the synthesis of jatrophanes, natural compounds with potential anti-cancer properties. It aims to develop new bioactive compounds that can modulate drug resistance in cancer cells, enhancing treatment efficacy.
AbstractJatrophane are natural compounds isolated from Euphorbia (Euphorbiaceae, spurge family).
More than 150 jathrophane have been isolated so far.
The general structure is an highly functionalized trans-bicyclo[10.3.0]pentadecane skeleton.
Jatrophanes possess a variety of different biological activities such as inhibitory activity on the mammalian mitochondrial respiratory chain, cell cleavage arrest, cytotoxicity against various human cancer cell lines, antiviral activity, antiplasmodial act…
UNIVERSITY OF GALWAY
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