CORDIS Project
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This project explores the potential of modular biosynthetic enzymes to create complex natural products with therapeutic applications. By studying trans-acyltransferase polyketide synthases, it aims to harness their diversity for synthetic biology and metabolic engineering.
Creating true molecular complexity in a modular, combinatorial fashion is one of the great visions in applied enzymology and chemistry.
Nature achieves this feat by using modular biosynthetic enzymes.
These microbial proteins generate many of the most important natural products of therapeutic value, including antiinfective, anticancer, and immunosuppressive agents.
To construct such compounds, each enzyme module incorporates and often modifies one building block in an assembly line-like process.…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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