CORDIS Project
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This project develops a platform for mapping synapses in the brain to understand their complexity and role in cognitive disorders. It aims to reveal how synaptic architecture is altered by mutations linked to conditions like schizophrenia and autism.
Synapses are a hallmark of the brain, showing remarkable anatomical and molecular complexity, and central to the aetiology and progression of hundreds of brain diseases.
The vertebrate brain has a vast potential synapse diversity arising from the differential distribution of combinations of proteins into individual synapses.
This has led to the recognition that “synaptome mapping” needs to be developed where the expression level of individual proteins is robustly measured in individual synapses…
THE UNIVERSITY OF EDINBURGH
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