CORDIS Project
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This project investigates the role of the SYNGAP1 gene and its isoforms in brain development and function, particularly in relation to SYNGAP1-related intellectual disability. It employs advanced techniques to explore how different isoforms affect neuronal communication and synaptic plasticity, aiming to uncover potent…
Synaptic Ras GTPase activating protein (SynGAP) is crucial for neuronal communication and is highly concentrated in excitatory synapses.
Mutations in the SYNGAP1 gene cause SYNGAP1-related intellectual disability (SRID), a neurodevelopmental disorder characterized by epilepsy, developmental delay, and autism.
As there is no cure for SRID, this proposal will elucidate SYNGAP1 expression and function during development.
In the adult brain, SynGAP regulates synaptic plasticity by interacting with o…
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United States, Philadelphia
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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