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The SYNFOS project focuses on advancing fragment-based ligand discovery to develop new drug candidates. It aims to enhance synthetic methods for modifying small chemical fragments to create effective inhibitors for protein-protein interactions, particularly targeting the ATAD2 bromodomain.
Fragment-based ligand discovery (FBLD) has become a mainstream strategy to discover new drugs to enable the treatment of conditions with unmet medical needs.
Despite the remarkable rise of FBLD, significant chemical challenges remain in the field; firstly, elaborated fragments tend to be synthesised de novo when direct growth would be much more advantageous.
Secondly, the currently available toolkit for fragment elaboration tends to exacerbate an uneven exploration of chemical space, yielding fl…
UNIVERSITY OF LEEDS
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