CORDIS Project
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This project explores the regulation of feeding behavior and metabolism by specific neurons in the hypothalamus. It aims to understand the molecular and functional diversity of these neurons to develop targeted therapies for metabolic disorders like obesity and diabetes.
Proopiomelanocortin (POMC)- and Agouti-Related Peptide (AgRP)-expressing, i.e. melanocortin neurons in the hypothalamus, are key regulators of feeding behaviour, glucose metabolism, autonomic responses and higher cognitive functions.
They represent targets for fuel-sensing hormones like leptin and insulin that thereby control key processes in systemic energy and glucose homeostasis.
Importantly, resistance to these fuel-sensing signals is known to contribute to the current obesity and diabetes e…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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