CORDIS Project
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This project investigates how syncytial muscle cells organize gene expression among multiple nuclei, focusing on the neuromuscular junction and myotendinous junction. It aims to understand the specification and maintenance of diverse nuclear identities and their roles in muscle function and disease.
Due to their cellular anatomy, syncytial cells face many unique challenges that mono-nucleated cells do not.
One of them is how syncytial cells organize gene expression among many nuclei in a shared cytoplasm.
How such property is linked to their biological functions remains poorly understood.
Using the skeletal muscle as a paradigm and single-nucleus transcriptomics, I recently uncovered previously unrecognized diversity and dynamics of myonuclear transcriptional programs.
This conceptualized t…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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France, Illkirch Graffenstaden
Type: Research institute
Activity type: Research Organisations
SME: No
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