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The SynarchiC project aims to characterize the folding patterns of microbial genomes throughout the cell cycle using advanced chromosome conformation capture technology. This research will enhance understanding of chromosome organization and its implications for gene regulation and pathogen interactions.
The folding of eukaryotic and prokaryotic chromosomes consists of an assortment of intertwined structural features.
The resulting complex networks of contacts is highly dynamic and interacts functionally with, or regulates metabolic processes ranging from gene expression to chromosome segregation.
Some higher order structures involve evolutionary conserved molecular players, such as structural maintenance of chromosomes (SMC) proteins, while others depend on phylum specific proteins.
The functio…
INSTITUT PASTEUR
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