CORDIS Project
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The SYNarch project aims to investigate the protein architecture of synapses in the brain, focusing on their diversity and changes in conditions like autism and schizophrenia. By employing advanced imaging and biochemical techniques, it seeks to create a detailed atlas of synapse structures and their spatial organizati…
Synapses play an essential role in all behaviours and damage to synapse proteins results in over a 130 brain disorders.
The host Grant lab has developed methods for brain-wide mapping of protein composition at single-synapse resolution, uncovering unexpected diversity.
The different synapse types show unique spatiotemporal distributions in the brain across the lifespan, which are altered in genetic models of autism and schizophrenia.
Synapse proteins are assembled into multiprotein complexes and…
THE UNIVERSITY OF EDINBURGH
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