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The SynaptoMitophagy project investigates how age-related mitochondrial damage affects synaptic function in neurons. By using advanced techniques on the nematode Caenorhabditis elegans and mammalian neurons, the project aims to understand the role of mitochondrial maintenance in brain health and aging.
Age-dependent accumulation of damaged mitochondria and synaptic loss represent early pathological hallmarks of brain ageing leading to neuronal death.
Mitochondria-selective autophagy (mitophagy) is triggered to eliminate defective organelles promoting cellular and organismal survival.
Mitophagy declines with age, while its induction extends lifespan and confers neuroprotection across diverse species.
Although the pivotal role of mitophagy in neuronal physiology is steadily emerging, its contrib…
ETHNIKO KAI KAPODISTRIAKO PANEPISTIMIO ATHINON
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