CORDIS Project
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This project investigates the distribution and role of the endoplasmic reticulum in presynaptic terminals of neurons, focusing on its implications for hereditary spastic paraplegia. Using Drosophila as a model organism, it aims to understand how mutations in ER-shaping proteins affect synaptic function and contribute t…
In neurons, endoplasmic reticulum (ER) organelle shows physical continuity between dendrites, cell body and axonal presynaptic terminals, and has been termed “a neuron within a neuron”.
The importance of ER in axons is suggested by the fact that mutations of ER-shaping proteins result in hereditary spastic paraplegia (HSP), a motor axon degeneration disease. ER is present in presynapses, and mutations of ER-shaping proteins disrupt synaptic morphology or function.
However, the physiological role…
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