CORDIS Project
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This project investigates the role of N-Methyl-D-Aspartate receptors in synaptic function and their link to neurological disorders. By studying the effects of genetic variants on neuronal communication, it aims to uncover mechanisms underlying various cognitive and psychiatric conditions.
N-Methyl-D-Aspartate (NMDA) receptors, play a critical role in synaptic plasticity and are linked to various neurological disorders.
Recent advancements in genetic sequencing have identified numerous variants in the GRIN2A gene, encoding the NMDAR receptor subunit GluN2A, to be associated with severe clinical outcomes, including intellectual disability, epileptic encephalopathy, speech and language impairments, and psychiatric illness.
Yet, the specific mechanisms underlying the pathophysiology…
THE UNIVERSITY OF EDINBURGH
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