CORDIS Project
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This project investigates the interactions of alpha-synuclein, a protein linked to Parkinson's disease, with other disordered proteins, particularly focusing on the neuronal plasma membrane calcium ATPase. By employing advanced biophysical techniques, the research aims to enhance understanding of protein interactions t…
Alpha-synuclein (aSN) is an intrinsically disordered protein (IDP) expressed by neurons, and well-known to aggregate in so-called Lewy bodies (LB) that are a hallmark of Parkinson’s disease (PD) and other LB disorders.
Despite extensive research, the mechanisms underlying its toxicity in these disorders still remains to be understood.
In this project, I will determine whether aSN can interact with other disordered proteins in a novel, mean-field type interaction, focusing on the disordered loop…
KOBENHAVNS UNIVERSITET
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