CORDIS Project
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This project aims to develop a targeted electrical neuroprosthesis to treat autonomic dysfunction following severe spinal cord injury. By mapping sympathetic circuitry, the research seeks to rehabilitate cardiovascular control and improve the quality of life for affected individuals.
Severe spinal cord injury (SCI) interrupts descending sympatho-excitatory axons responsible for cardiovascular control.
Devoid of supraspinal input, sympathetic circuits within the spinal cord undergo significant plastic changes.
These changes lead to a debilitating clinical scenario that includes frequent bouts of hypertension (autonomic dysreflexia) and orthostatic hypotension, conditions which have extremely limited treatment options and lead to increased risk for cardiovascular disease.
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ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE
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