CORDIS Project
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This project aims to develop a novel method for engineering B cells to produce anti-HIV antibodies without using CRISPR/Cas9, enhancing safety and effectiveness. The approach, termed 'Switch Targeting,' seeks to provide a potential single-shot cure for HIV by utilizing adeno-associated viral vectors to target specific…
Chronic antiretroviral therapy (ART) does not eradicate HIV infection.
As a potentially single-shot alternative, B cells engineered by CRISPR/Cas9 to express anti-HIV broadly neutralizing antibodies (bNAbs) were shown capable of secreting high and neutralizing antibody titers.
In particular, we previously demonstrated that, upon immunization of mice, adoptively transferred B cells, that were engineered at the immunoglobulin heavy (IgH) locus by CRISPR/Cas9, differentiate into memory and plasma c…
TEL AVIV UNIVERSITY
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