CORDIS Project
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This project investigates how mechanical forces influence the structure and function of proteins, particularly focusing on the extracellular matrix protein fibronectin and its interactions with cells. The goal is to understand mechanotransduction and its implications for cellular behavior and potential technological ap…
After a decade of new insights into single molecule mechanics, my key interests are now directed towards asking how (a) mechanical forces can alter the structure-function relationship of proteins and (b) whether such force-regulated structural alterations are of physiological significance.
Since forces are applied by cells via the transmembrane integrin junctions to the extracellular matrix, my goal is to decipher how the extracellular matrix protein fibronectin, integrins, and cytoplasmic scaff…
EIDGENOESSISCHE TECHNISCHE HOCHSCHULE ZUERICH
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