CORDIS Project
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The SWITCH-HD project investigates the role of mutant Huntingtin protein in Huntington Disease by targeting specific brain regions. Using a transgenic rat model, the project aims to understand how this protein affects behavior, metabolism, and potential biomarkers, ultimately leading to more precise treatments for the…
Huntington Disease (HD) is an autosomal dominantly inherited neurodegenerative disorder, which is caused by an expanded CAG repeat in the huntingtin gene.
Mutant Huntingtin (mhtt) is expressed ubiquitously in the brain but the most affected region is the striatum.
Marked atrophy also occurs in other brain regions such as the cortex and the hypothalamus.
The latter has been linked to disturbances in sleep pattern, energy metabolism and emotion, all of them non-motor symptoms of HD that occur earl…
EBERHARD KARLS UNIVERSITAET TUEBINGEN
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Austria, GRAMBACH
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
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