CORDIS Project
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This project develops a light-responsive tool to study G-Quadruplexes, four-stranded DNA structures, in living cells. By controlling the folding of these structures, it aims to clarify their role in gene expression and regulatory processes.
Guanine-rich (G-rich) oligonucleotides can fold into G-Quadruplexes (G4s), four-stranded DNA structures involved in the fine regulation of key cellular processes. G4s are found in telomeres, oncogene promoters (kRAS, cMYC, BCL2), and non-coding RNA, where they likely play important roles in transcription and translation.
Despite extensive research, the precise regulatory function of G4s remains unclear, and key questions such as whether G4 formation actively drives gene expression or is a bypro…
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